Skeletal Myoblasts for Cardiac Repair: Act II?
نویسندگان
چکیده
منابع مشابه
Skeletal myoblasts for cardiac repair: Act II?
s t c en years ago, when the increased prevalence of heart ailure along with the recognition of the limitations of xisting therapies have forced the consideration of new herapeutic options, implantation of contractile cells into carred myocardium has emerged as an attractive strategy. his approach was actually backed by the long-standing uccessful outcomes of bone marrow and skin transplantaion...
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The real promise of a stem cell-based approach for cardiac regeneration and repair lies in the promotion of myogenesis and angiogenesis at the site of the cell graft to achieve both structural and functional benefits. Despite all of the progress and promise in this field, many unanswered questions remain; the answers to these questions will provide the much-needed breakthrough to harness the re...
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BACKGROUND We investigated the feasibility and efficacy of polyethylenimine (PEI) based human vascular endothelial growth factor-165 (hVEGF165) gene transfer into human skeletal myoblasts (HSM) for cell based delivery to the infarcted myocardium. METHODS AND RESULTS Based on optimized transfection procedure using enhanced green fluorescent protein (pEGFP), HSM were transfected with plasmid-hV...
متن کاملAntiarrhythmic engineering of skeletal myoblasts for cardiac transplantation.
Skeletal myoblasts are an attractive cell type for transplantation because they are autologous and resistant to ischemia. However, clinical trials of myoblast transplantation in heart failure have been plagued by ventricular tachyarrhythmias and sudden cardiac death. The pathogenesis of these arrhythmias is poorly understood, but may be related to the fact that skeletal muscle cells, unlike hea...
متن کاملCombined transplantation of skeletal myoblasts and bone marrow stem cells for myocardial repair in rats.
OBJECTIVES To prove whether intramyocardial transplantation of combined skeletal myoblasts (SM) and mononuclear bone marrow stem cells is superior to the isolated transplantation of these cell types after myocardial infarction in rats. METHODS In 67 male Fischer rats myocardial infarction was induced by direct ligature of the LAD. Seven days postinfarction baseline echocardiography and intram...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2008
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2008.07.066